<p><span>We invite applications for a postdoctoral position in the eBERlight group within the X-ray Science Division at Argonne National Laboratory. The selected candidate will lead </span>the expansion of the protein expression platforms, currently utilizing E. coli and mammalian cell lines, to onboard other microbial systems (e.g., fungi), insect-cell (baculovirus) systems, plant-based expression (in planta), and cell free methods.</p><p></p><p>Key Responsibilities:</p><ul><li><p>Development and optimization of vector constructs and expression condition characterization of protein yields and quality, and large-scale protein production for structural biology and other applications (ligand binding, enzymatic activity etc.).</p></li><li><p>Involvement in the research pertinent to specific protein targets will be expected as well, along with presentation of findings <span>to the community through publications and presentations.</span> </p></li></ul><p style="text-align:inherit;"></p><p style="text-align:inherit;"></p><p style="text-align:left;"><b>Position Requirements</b></p><ul><li><p>Ph.D. in Molecular Biology, Biochemistry, Biotechnology, Plant Biology, Protein Engineering, Microbiology, or a related field completed in the past five years or soon-to-be completed.</p></li><li><p>Demonstrated experience in at least two of the following:</p><ul><li><p>Fungal protein expression</p></li><li><p>Insect-cell (baculovirus) expression platforms.</p></li><li><p>Plant-based (in planta) expression systems.</p></li><li><p>Membrane proteins production and purification</p></li></ul></li><li><p>Strong molecular biology skills (cloning, vector design, transformation), protein purification and analysis, and quantitative data analysis.</p></li><li><p>Excellent communication and teamwork capabilities, with a track record (or potential) in writing publications and presenting scientific results.</p></li><li><p>Interpersonal skills, oral and written communication skills, and ability to interact with people at all levels both within and outside the laboratory.</p></li><li><p>Ability to model Argonne’s core values of impact, safety, respect, integrity, and teamwork.</p></li></ul><p></p><p><b>Preferred Knowledge, Skills, and Experience</b></p><ul><li><p>Prior experience with high-throughput or computational protein design/screening techniques.</p></li><li><p>Background in structural biology (CryoEM/crystallography)</p></li><li><p>Knowledge of in planta systems—stable or transient expression, agroinfiltration techniques, or engineering of plant chassis.</p></li></ul><p style="text-align:inherit;"></p><p style="text-align:inherit;"></p><p style="text-align:left;"><b>Job Family</b></p>Postdoctoral<p style="text-align:inherit;"></p><p style="text-align:inherit;"></p><p style="text-align:left;"><b>Job Profile</b></p>Postdoctoral Appointee<p style="text-align:inherit;"></p><p style="text-align:inherit;"></p><p style="text-align:left;"><b>Worker Type</b></p>Long-Term (Fixed Term)<p style="text-align:inherit;"></p><p style="text-align:inherit;"></p><p style="text-align:left;"><b>Time Type</b></p>Full time<p style="text-align:inherit;"></p><p style="text-align:inherit;"></p><h3></h3>The expected hiring range for this position is $70,758.00-$117,925.00.<h3></h3><p style="text-align:inherit;"></p><p style="text-align:left;"><span><span>Please note that the pay range information is a general guideline only. The pay offered to a selected candidate will be determined based on factors such as, but not limited to, the scope and responsibilities of the position, the qualifications of the selected candidate, business considerations, internal equity, and external market pay for comparable jobs. Additionally, comprehensive benefits are part of the total rewards package. </span></span></p><p style="text-align:inherit;"></p><p style="text-align:left;">Click <a href="https://www.anl.gov/hr/healthcare-insurance"><span>here</span></a> to view Argonne employee benefits!</p><h3></h3><p style="text-align:inherit;"></p><p><span>As an equal employment opportunity employer, and in accordance with our core values of impact, safety, respect, integrity and teamwork, Argonne National Laboratory is committed to a safe and welcoming workplace that fosters collaborative scientific discovery and innovation. Argonne encourages everyone to apply for employment. Argonne is committed to nondiscrimination and considers all qualified applicants for employment without regard to any characteristic protected by law.</span></p><p style="text-align:inherit;"></p><p style="text-align:inherit;"></p><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><p style="text-align:left;">Argonne employees, and certain guest researchers and contractors, are subject to particular restrictions related to participation in Foreign Government Sponsored or Affiliated Activities, as defined and detailed in United States Department of Energy Order 486.1A. You will be asked to disclose any such participation in the application phase for review by Argonne's Legal Department.  </p><p style="text-align:inherit;"></p><p style="text-align:left;">All Argonne offers of employment are contingent upon a background check that includes an assessment of criminal conviction history conducted on an individualized and case-by-case basis.  Please be advised that Argonne positions require upon hire (or may require in the future) for the individual be to obtain a government access authorization that involves additional background check requirements.  Failure to obtain or maintain such government access authorization could result in the withdrawal of a job offer or future termination of employment.</p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

<p class="break-words white-space-pre-wrap t-black--light text-body-medium">Argonne National Laboratory, one of the U.S. Department of Energy's national laboratories for science and engineering research, employs 3,400 employees, including 1,400 scientists and engineers, three-quarters of whom hold doctoral degrees. Argonne's annual operating budget of around $1 billion supports upwards of 200 research projects. Since 1990, Argonne has worked with more than 600 companies and numerous federal agencies and other organizations. Argonne's mission is to apply a unique mix of world-class science, engineering and user facilities to deliver innovative research and technologies. We create new knowledge that addresses the most important scientific and societal needs of our nation. We actively seek opportunities to work with industry to transfer our technologies to the marketplace through licensing, joint research and many other collaborative relationships. Argonne is managed by UChicago Argonne, LLC, for the U.S. Department of Energy's Office of Science. We are located on 1,500 acres (6.9 sq. km) in southwest DuPage County, Illinois 25 miles (40 km) southwest of Chicago. The site is completely encircled by the beautiful Waterfall Glen Forest Preserve.</p>

Postdoctoral Appointee - Development of Multi-Platform Protein Expression Systems

<p><span>We invite applications for a postdoctoral position in the eBERlight group within the X-ray Science Division at Argonne National Laboratory. The selected candidate will lead </span>the expansion of the protein expression platforms, currently utilizing E. coli and mammalian cell lines, to onboard other microbial systems (e.g., fungi), insect-cell (baculovirus) systems, plant-based expression (in planta), and cell free methods.</p><p></p><p>Key Responsibilities:</p><ul><li><p>Development and optimization of vector constructs and expression condition characterization of protein yields and quality, and large-scale protein production for structural biology and other applications (ligand binding, enzymatic activity etc.).</p></li><li><p>Involvement in the research pertinent to specific protein targets will be expected as well, along with presentation of findings <span>to the community through publications and presentations.</span>&nbsp;</p></li></ul><p></p><p></p><p><b>Position Requirements</b></p><ul><li><p>Ph.D. in Molecular Biology, Biochemistry, Biotechnology, Plant Biology, Protein Engineering, Microbiology, or a related field completed in the past five years or soon-to-be completed.</p></li><li><p>Demonstrated experience in at least two of the following:</p><ul><li><p>Fungal protein expression</p></li><li><p>Insect-cell (baculovirus) expression platforms.</p></li><li><p>Plant-based (in planta) expression systems.</p></li><li><p>Membrane proteins production and purification</p></li></ul></li><li><p>Strong molecular biology skills (cloning, vector design, transformation), protein purification and analysis, and quantitative data analysis.</p></li><li><p>Excellent communication and teamwork capabilities, with a track record (or potential) in writing publications and presenting scientific results.</p></li><li><p>Interpersonal skills, oral and written communication skills, and ability to interact with people at all levels both within and outside the laboratory.</p></li><li><p>Ability to model Argonne’s core values of impact, safety, respect, integrity, and teamwork.</p></li></ul><p></p><p><b>Preferred Knowledge, Skills, and Experience</b></p><ul><li><p>Prior experience with high-throughput or computational protein design/screening techniques.</p></li><li><p>Background in structural biology (CryoEM/crystallography)</p></li><li><p>Knowledge of in planta systems—stable or transient expression, agroinfiltration techniques, or engineering of plant chassis.</p></li></ul><p></p><p></p><p><b>Job Family</b></p>Postdoctoral<p></p><p></p><p><b>Job Profile</b></p>Postdoctoral Appointee<p></p><p></p><p><b>Worker Type</b></p>Long-Term (Fixed Term)<p></p><p></p><p><b>Time Type</b></p>Full time<p></p><p></p><h3></h3>The expected hiring range for this position is $70,758.00-$117,925.00.<h3></h3><p></p><p><span><span>Please note that the pay range information is a general guideline only. The pay offered to a selected candidate will be determined based on factors such as, but not limited to, the scope and responsibilities of the position, the qualifications of the selected candidate, business considerations, internal equity, and external market pay for comparable jobs. Additionally, comprehensive benefits are part of the total rewards package. </span></span></p><p></p><p>Click <a href="https://www.anl.gov/hr/healthcare-insurance"><span>here</span></a> to view Argonne employee benefits!</p><h3></h3><p></p><p><span>As an equal employment opportunity employer, and in accordance with our core values of impact, safety, respect, integrity and teamwork, Argonne National Laboratory is committed to a safe and welcoming workplace that fosters collaborative scientific discovery and innovation. Argonne encourages everyone to apply for employment. Argonne is committed to nondiscrimination and considers all qualified applicants for employment without regard to any characteristic protected by law.</span></p><p></p><p></p><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><div><p>Argonne employees, and certain guest researchers and contractors, are subject to particular restrictions related to participation in Foreign Government Sponsored or Affiliated Activities, as defined and detailed in United States Department of Energy Order 486.1A. You will be asked to disclose any such participation in the application phase for review by Argonne's Legal Department. &nbsp;</p><p></p><p>All Argonne offers of employment are contingent upon a background check that includes an assessment of criminal conviction history conducted on an individualized and case-by-case basis. &nbsp;Please be advised that Argonne positions require upon hire (or may require in the future) for the individual be to obtain a government access authorization that involves additional background check requirements. &nbsp;Failure to obtain or maintain such government access authorization could result in the withdrawal of a job offer or future termination of employment.</p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Postdoctoral Appointee - Development of Multi-Platform Protein Expression Systems

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Argonne National Laboratory

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