Colossal is seeking a Research Associate to support genome engineering projects in mammalian systems by performing core molecular biology workflows, including plasmid preparation, PCR, gel electrophoresis, and DNA quality control. This role will also assist with routine lab operations in support of the Thylacine team. Working closely with senior team members, the Research Associate will contribute to Colossal’s mission of advancing genome engineering technologies for de-extinction and conservation. This position is based on-site in Dallas, TX. Relocation assistance is available. Duties and Responsibilities:<ul><li>Work with senior lab members to support the design, development, and testing of multiplex genome engineering tools in mammalian cells</li><li>Perform routine molecular biology workflows, including plasmid DNA preparation (mini/midi/maxi preps), PCR, gel electrophoresis, and gel analysis</li><li>Assist with general lab operations, such as inventory management, preparation of common stocks, and basic equipment maintenance</li><li>Work on project milestones, attend team meetings, prepare progress reports, and presentations</li></ul><h3>Required Skills and Abilities</h3><ul><li>Ability to thrive in a fast-paced environment</li><li>Strong written and oral communication skills, as well as creative problem-solving skills</li><li>Great organizational skills and excellent laboratory record maintenance</li><li>Proficiency in aseptic technique for E. coli culture and handling</li><li>Hands-on experience with core molecular biology techniques, including plasmid DNA preparation (mini/midi/maxi preps), genomic DNA preparation, PCR, gel electrophoresis, and DNA quality control</li><li>Familiarity with sequence analysis software (e.g., SnapGene, Geneious)</li></ul>Preferred Skills and Abilities<ul><li>Experience with RNA extraction, RNA handling, and qPCR methods</li><li>Familiarity with electronic lab notebooks (ELN) and laboratory inventory management systems</li><li>Prior experience with cloning techniques (restriction enzyme–based cloning, Gibson assembly, or similar methods)</li></ul><h3>Education and Experience:</h3><ul><li>Bachelors in biological sciences, bioengineering, molecular biology, genetics, or any science related field</li><li>Previous experience as a Research Associate or technician in an academic or biotechnology industry setting is a plus</li></ul><h3>What We Value</h3>Colossal’s Genome Engineering team emphasizes collaboration, transparency, and mutual support. We are committed to maintaining a culture where every team member — from Research Associate to Scientist — contributes meaningfully to scientific progress, while respecting the importance of shared responsibility and collective success.<div>What Colossal Offers You:<ul><li style="font-weight:400;">Medical, dental, and vision coverage</li><li style="font-weight:400;">Unlimited PTO and company holidays so you can rest and recharge </li><li style="font-weight:400;">Flexible spending accounts (FSA)</li><li style="font-weight:400;">Company matched 401k retirement plan</li><li style="font-weight:400;">Paid parental leave up to 12 weeks</li><li style="font-weight:400;">Education reimbursement </li><li style="font-weight:400;">An opportunity to help us return the Earth to a healthier state</li></ul>The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices. Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive. <a href="https://www.eeoc.gov/after-june-27-2023-know-your-rights-workplace-discrimination-illegal">EEO is the Law </a>Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house. Colossal is proud to be named a Best Place to Work by BuiltIn for 3 years in a row across multiple categories in 2023, 2024, and 2025:<ul><li>#1 on the 50 Best Startups to Work For in Dallas in 2023!</li><li>100 Best Midsize Places to Work in Dallas in 2024 &amp; 2025</li><li>100 Best Places to Work in Dallas, TX (All Size Employers) in 2024 &amp; 2025</li></ul> <a href="https://builtin.com/awards/dallas/2025/best-midsize-places-to-work">Built In 2025 Award Lists</a><a href="https://www.greatplacetowork.com/certified-company/7049203">Great Place to Work Certification Page</a><a href="https://mostlovedworkplace.com/companies/colossal-biosciences/">Most Loved Workplace Certification Page</a> - Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals.<a href="https://www.newsweek.com/rankings/most-loved-workplaces-2024?utm_campaign=dr_2024_oct_webinar_final&amp;utm_medium=email&amp;_hsenc=p2ANqtz-8dglCEGpx_mr-HYudRKFhj4L6PhGDkf92pJJMpxovuNaX_Y7rdOFsgX6dEGZnNK9O_RP1gd54PPR7yib9CZjvG7FT4IA&amp;_hsmi=328042950&amp;utm_content=see_list&amp;utm_source=newlsetter">Newsweek's Most Loved Workplaces 2024 Award List</a> - Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces! <img src="https://employers.builtin.com/wp-content/uploads/2023/09/2024BPTW_GeneralBadgeYear_AllWhite-1-281x300.png" style="max-width:100%;">   <img src="https://www.greatplacetowork.com/images/profiles/7049203/companyBadge.png?20240207" style="max-width:100%;">     <img src="https://pbs.twimg.com/media/FvJDPn0aEAAwgAH?format=jpg&amp;name=small" style="max-width:100%;">    <img src="https://colossal.com/wp-content/uploads/time-100.png" style="max-width:100%;"> <img src="https://imageio.forbes.com/dam/imageserve/65e730dcd08766cc9dbcdb47/x.jpg?format=jpg&amp;height=183&amp;width=255&amp;fit=bounds" style="max-width:100%;"> </div>

The science of genetics. The business of discovery.
Colossal is a breakthrough bioscience and genetic engineering company that builds radical new technologies to advance the field of genomics. Colossal creates disruptive technologies for extinct species restoration, critically endangered species protection and the repopulation of critical ecosystems that support the continuation of life on Earth. The company is the first to apply CRISPR technology for the purposes of species de-extinction, beginning with the woolly mammoth. Colossal is accepting humanity&rsquo;s duty to restore Earth to a healthier state, while also solving for the future economies and biological necessities of the human condition through cutting-edge science and technologies.

Research Associate, Genome Engineering

Colossal is seeking a Research Associate to support genome engineering projects in mammalian systems by performing core molecular biology workflows, including plasmid preparation, PCR, gel electrophoresis, and DNA quality control. This role will also assist with routine lab operations in support of the Thylacine team. Working closely with senior team members, the Research Associate will contribute to Colossal’s mission of advancing genome engineering technologies for de-extinction and conservation.&nbsp;This position is based on-site in Dallas, TX. Relocation assistance is available.&nbsp;Duties and Responsibilities:<ul><li>Work with senior lab members to support the design, development, and testing of multiplex genome engineering tools in mammalian cells</li><li>Perform routine molecular biology workflows, including plasmid DNA preparation (mini/midi/maxi preps), PCR, gel electrophoresis, and gel analysis</li><li>Assist with general lab operations, such as inventory management, preparation of common stocks, and basic equipment maintenance</li><li>Work on project milestones, attend team meetings, prepare progress reports, and presentations</li></ul><h3>Required Skills and Abilities</h3><ul><li>Ability to thrive in a fast-paced environment</li><li>Strong written and oral communication skills, as well as creative problem-solving skills</li><li>Great organizational skills and excellent laboratory record maintenance</li><li>Proficiency in aseptic technique for E. coli culture and handling</li><li>Hands-on experience with core molecular biology techniques, including plasmid DNA preparation (mini/midi/maxi preps), genomic DNA preparation, PCR, gel electrophoresis, and DNA quality control</li><li>Familiarity with sequence analysis software (e.g., SnapGene, Geneious)</li></ul>Preferred Skills and Abilities<ul><li>Experience with RNA extraction, RNA handling, and qPCR methods</li><li>Familiarity with electronic lab notebooks (ELN) and laboratory inventory management systems</li><li>Prior experience with cloning techniques (restriction enzyme–based cloning, Gibson assembly, or similar methods)</li></ul><h3>Education and Experience:</h3><ul><li>Bachelors in biological sciences, bioengineering, molecular biology, genetics, or any science related field</li><li>Previous experience as a Research Associate or technician in an academic or biotechnology industry setting is a plus</li></ul><h3>What We Value</h3>Colossal’s Genome Engineering team emphasizes collaboration, transparency, and mutual support. We are committed to maintaining a culture where every team member — from Research Associate to Scientist — contributes meaningfully to scientific progress, while respecting the importance of shared responsibility and collective success.<div>What Colossal Offers You:<ul><li>Medical, dental, and vision coverage</li><li>Unlimited PTO and company holidays so you can rest and recharge&nbsp;</li><li>Flexible spending accounts (FSA)</li><li>Company matched 401k retirement plan</li><li>Paid parental leave up to 12 weeks</li><li>Education reimbursement&nbsp;</li><li>An opportunity to help us return the Earth to a healthier state</li></ul>The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices.&nbsp;Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive.&nbsp;<a href="https://www.eeoc.gov/after-june-27-2023-know-your-rights-workplace-discrimination-illegal">EEO is the Law&nbsp;</a>Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house.&nbsp;Colossal is proud to be named a Best Place to Work by BuiltIn for 3 years in a row across multiple categories in 2023, 2024, and 2025:<ul><li>#1 on the 50 Best Startups to Work For in Dallas in 2023!</li><li>100 Best Midsize Places to Work in Dallas in 2024 &amp; 2025</li><li>100 Best Places to Work in Dallas, TX (All Size Employers) in 2024 &amp; 2025</li></ul> <a href="https://builtin.com/awards/dallas/2025/best-midsize-places-to-work">Built In 2025 Award Lists</a><a href="https://www.greatplacetowork.com/certified-company/7049203">Great Place to Work Certification Page</a><a href="https://mostlovedworkplace.com/companies/colossal-biosciences/">Most Loved Workplace Certification Page</a> - Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals.<a href="https://www.newsweek.com/rankings/most-loved-workplaces-2024?utm_campaign=dr_2024_oct_webinar_final&amp;utm_medium=email&amp;_hsenc=p2ANqtz-8dglCEGpx_mr-HYudRKFhj4L6PhGDkf92pJJMpxovuNaX_Y7rdOFsgX6dEGZnNK9O_RP1gd54PPR7yib9CZjvG7FT4IA&amp;_hsmi=328042950&amp;utm_content=see_list&amp;utm_source=newlsetter">Newsweek's Most Loved Workplaces 2024 Award List</a> - Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces!&nbsp;<img src="https://employers.builtin.com/wp-content/uploads/2023/09/2024BPTW_GeneralBadgeYear_AllWhite-1-281x300.png">&nbsp; &nbsp;<img src="https://www.greatplacetowork.com/images/profiles/7049203/companyBadge.png?20240207">&nbsp; &nbsp; &nbsp;<img src="https://pbs.twimg.com/media/FvJDPn0aEAAwgAH?format=jpg&amp;name=small"> &nbsp; &nbsp;<img src="https://colossal.com/wp-content/uploads/time-100.png"> <img src="https://imageio.forbes.com/dam/imageserve/65e730dcd08766cc9dbcdb47/x.jpg?format=jpg&amp;height=183&amp;width=255&amp;fit=bounds">&nbsp;</div>

Research Associate, Genome EngineeringNew

About the Job

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Colossal Biosciences

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