The Scientist, Genome Engineering, will contribute to the development and optimization of genome engineering workflows, with a focus on molecular biology, editing technology innovation, and high-throughput workflow design. This role combines independent project ownership with active collaboration across the Genome Engineering team. In addition to advancing their own research, the Scientist will serve as a technical resource for research associates on established workflows, ensuring knowledge-sharing and teamwork remain central to day-to-day operations. The Scientist will work under the direction of the Genome Engineering Team Lead and in close coordination with other team members to help achieve Colossal’s mission of advancing genome engineering technologies for conservation.This position is based in Dallas, TX. Relocation assistance is available.Duties and Responsibilities<ul><li>Contribute to the design, implementation, and analysis of genome engineering workflows, including cloning, in vitro transcription, and large-cargo DNA delivery strategies</li><li>Lead independent project efforts in areas such as editing technology innovation and high-throughput workflow design, while coordinating closely with teammates to ensure integration of results</li><li>Serve as a technical resource to support research associates on established prime and base editing workflows, providing troubleshooting and data interpretation in a collaborative, mentorship-focused manner</li><li>Partner with team members to ensure timely execution of molecular biology tasks (cloning, DNA/RNA preps, QC, and handoffs), maintaining an equitable distribution of workload across the team</li><li>Document results clearly in electronic lab notebooks and share updates in team meetings and project discussions to promote transparency and collective progress</li><li>Contribute to the achievement of shared project milestones within the Genome Engineering program </li></ul>Required Skills and Abilities<ul><li>Strong expertise in molecular biology techniques, including cloning, plasmid preparation, PCR, gel electrophoresis, DNA/RNA QC, RNA extraction, RNA handling, and qPCR methods</li><li>Experience with genome editing tools (e.g., CRISPR-based systems, recombinases, or related technologies)</li><li>Ability to thrive in a highly collaborative team environment, serving as a resource for junior researchers while actively seeking input from peers and the Genome Engineering Lead</li><li>Strong critical thinking, problem-solving, and troubleshooting skills with a cooperative approach to challenges</li><li>Excellent written/oral communication and organizational skills, with meticulous record-keeping in ELNs</li><li>Comfort with the challenges of working in non-model species where tools and resources are limited</li></ul>Education and Experience<ul><li>PhD in molecular biology, genetics, bioengineering, synthetic biology, or a related field</li><li>Hands-on experience in genome editing or nucleic acid technology development</li></ul>Preferred Experience<ul><li>Prior work on prime editing, base editing, or large-cargo delivery systems</li><li>Experience developing or scaling high-throughput molecular workflows Familiarity with commonly used sequence design/analysis software (e.g., SnapGene, Geneious)</li></ul>What We ValueColossal’s Genome Engineering team emphasizes collaboration, transparency, and mutual support. We are committed to maintaining a culture where every team member — from Research Associate to Scientist — contributes meaningfully to scientific progress, while respecting the importance of shared responsibility and collective success. <div>What Colossal Offers You:<ul><li style="font-weight:400;">Medical, dental, and vision coverage</li><li style="font-weight:400;">Unlimited PTO and company holidays so you can rest and recharge </li><li style="font-weight:400;">Flexible spending accounts (FSA)</li><li style="font-weight:400;">Company matched 401k retirement plan</li><li style="font-weight:400;">Paid parental leave up to 12 weeks</li><li style="font-weight:400;">Education reimbursement </li><li style="font-weight:400;">An opportunity to help us return the Earth to a healthier state</li></ul>The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices. Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive. <a href="https://www.eeoc.gov/after-june-27-2023-know-your-rights-workplace-discrimination-illegal">EEO is the Law </a>Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house. Colossal is proud to be named a Best Place to Work by BuiltIn for 3 years in a row across multiple categories in 2023, 2024, and 2025:<ul><li>#1 on the 50 Best Startups to Work For in Dallas in 2023!</li><li>100 Best Midsize Places to Work in Dallas in 2024 &amp; 2025</li><li>100 Best Places to Work in Dallas, TX (All Size Employers) in 2024 &amp; 2025</li></ul> <a href="https://builtin.com/awards/dallas/2025/best-midsize-places-to-work">Built In 2025 Award Lists</a><a href="https://www.greatplacetowork.com/certified-company/7049203">Great Place to Work Certification Page</a><a href="https://mostlovedworkplace.com/companies/colossal-biosciences/">Most Loved Workplace Certification Page</a> - Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals.<a href="https://www.newsweek.com/rankings/most-loved-workplaces-2024?utm_campaign=dr_2024_oct_webinar_final&amp;utm_medium=email&amp;_hsenc=p2ANqtz-8dglCEGpx_mr-HYudRKFhj4L6PhGDkf92pJJMpxovuNaX_Y7rdOFsgX6dEGZnNK9O_RP1gd54PPR7yib9CZjvG7FT4IA&amp;_hsmi=328042950&amp;utm_content=see_list&amp;utm_source=newlsetter">Newsweek's Most Loved Workplaces 2024 Award List</a> - Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces! <img src="https://employers.builtin.com/wp-content/uploads/2023/09/2024BPTW_GeneralBadgeYear_AllWhite-1-281x300.png" style="max-width:100%;">   <img src="https://www.greatplacetowork.com/images/profiles/7049203/companyBadge.png?20240207" style="max-width:100%;">     <img src="https://pbs.twimg.com/media/FvJDPn0aEAAwgAH?format=jpg&amp;name=small" style="max-width:100%;">    <img src="https://colossal.com/wp-content/uploads/time-100.png" style="max-width:100%;"> <img src="https://imageio.forbes.com/dam/imageserve/65e730dcd08766cc9dbcdb47/x.jpg?format=jpg&amp;height=183&amp;width=255&amp;fit=bounds" style="max-width:100%;"> </div>

The science of genetics. The business of discovery.
Colossal is a breakthrough bioscience and genetic engineering company that builds radical new technologies to advance the field of genomics. Colossal creates disruptive technologies for extinct species restoration, critically endangered species protection and the repopulation of critical ecosystems that support the continuation of life on Earth. The company is the first to apply CRISPR technology for the purposes of species de-extinction, beginning with the woolly mammoth. Colossal is accepting humanity&rsquo;s duty to restore Earth to a healthier state, while also solving for the future economies and biological necessities of the human condition through cutting-edge science and technologies.

Scientist, Genome Engineering

The Scientist, Genome Engineering, will contribute to the development and optimization of genome engineering workflows, with a focus on molecular biology, editing technology innovation, and high-throughput workflow design. This role combines independent project ownership with active collaboration across the Genome Engineering team. In addition to advancing their own research, the Scientist will serve as a technical resource for research associates on established workflows, ensuring knowledge-sharing and teamwork remain central to day-to-day operations. The Scientist will work under the direction of the Genome Engineering Team Lead and in close coordination with other team members to help achieve Colossal’s mission of advancing genome engineering technologies for conservation.This position is based in Dallas, TX. Relocation assistance is available.Duties and Responsibilities<ul><li>Contribute to the design, implementation, and analysis of genome engineering workflows, including cloning, in vitro transcription, and large-cargo DNA delivery strategies</li><li>Lead independent project efforts in areas such as editing technology innovation and high-throughput workflow design, while coordinating closely with teammates to ensure integration of results</li><li>Serve as a technical resource to support research associates on established prime and base editing workflows, providing troubleshooting and data interpretation in a collaborative, mentorship-focused manner</li><li>Partner with team members to ensure timely execution of molecular biology tasks (cloning, DNA/RNA preps, QC, and handoffs), maintaining an equitable distribution of workload across the team</li><li>Document results clearly in electronic lab notebooks and share updates in team meetings and project discussions to promote transparency and collective progress</li><li>Contribute to the achievement of shared project milestones within the Genome Engineering program </li></ul>Required Skills and Abilities<ul><li>Strong expertise in molecular biology techniques, including cloning, plasmid preparation, PCR, gel electrophoresis, DNA/RNA QC, RNA extraction, RNA handling, and qPCR methods</li><li>Experience with genome editing tools (e.g., CRISPR-based systems, recombinases, or related technologies)</li><li>Ability to thrive in a highly collaborative team environment, serving as a resource for junior researchers while actively seeking input from peers and the Genome Engineering Lead</li><li>Strong critical thinking, problem-solving, and troubleshooting skills with a cooperative approach to challenges</li><li>Excellent written/oral communication and organizational skills, with meticulous record-keeping in ELNs</li><li>Comfort with the challenges of working in non-model species where tools and resources are limited</li></ul>Education and Experience<ul><li>PhD in molecular biology, genetics, bioengineering, synthetic biology, or a related field</li><li>Hands-on experience in genome editing or nucleic acid technology development</li></ul>Preferred Experience<ul><li>Prior work on prime editing, base editing, or large-cargo delivery systems</li><li>Experience developing or scaling high-throughput molecular workflows Familiarity with commonly used sequence design/analysis software (e.g., SnapGene, Geneious)</li></ul>What We ValueColossal’s Genome Engineering team emphasizes collaboration, transparency, and mutual support. We are committed to maintaining a culture where every team member — from Research Associate to Scientist — contributes meaningfully to scientific progress, while respecting the importance of shared responsibility and collective success.&nbsp;<div>What Colossal Offers You:<ul><li>Medical, dental, and vision coverage</li><li>Unlimited PTO and company holidays so you can rest and recharge&nbsp;</li><li>Flexible spending accounts (FSA)</li><li>Company matched 401k retirement plan</li><li>Paid parental leave up to 12 weeks</li><li>Education reimbursement&nbsp;</li><li>An opportunity to help us return the Earth to a healthier state</li></ul>The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices.&nbsp;Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive.&nbsp;<a href="https://www.eeoc.gov/after-june-27-2023-know-your-rights-workplace-discrimination-illegal">EEO is the Law&nbsp;</a>Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house.&nbsp;Colossal is proud to be named a Best Place to Work by BuiltIn for 3 years in a row across multiple categories in 2023, 2024, and 2025:<ul><li>#1 on the 50 Best Startups to Work For in Dallas in 2023!</li><li>100 Best Midsize Places to Work in Dallas in 2024 &amp; 2025</li><li>100 Best Places to Work in Dallas, TX (All Size Employers) in 2024 &amp; 2025</li></ul> <a href="https://builtin.com/awards/dallas/2025/best-midsize-places-to-work">Built In 2025 Award Lists</a><a href="https://www.greatplacetowork.com/certified-company/7049203">Great Place to Work Certification Page</a><a href="https://mostlovedworkplace.com/companies/colossal-biosciences/">Most Loved Workplace Certification Page</a> - Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals.<a href="https://www.newsweek.com/rankings/most-loved-workplaces-2024?utm_campaign=dr_2024_oct_webinar_final&amp;utm_medium=email&amp;_hsenc=p2ANqtz-8dglCEGpx_mr-HYudRKFhj4L6PhGDkf92pJJMpxovuNaX_Y7rdOFsgX6dEGZnNK9O_RP1gd54PPR7yib9CZjvG7FT4IA&amp;_hsmi=328042950&amp;utm_content=see_list&amp;utm_source=newlsetter">Newsweek's Most Loved Workplaces 2024 Award List</a> - Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces!&nbsp;<img src="https://employers.builtin.com/wp-content/uploads/2023/09/2024BPTW_GeneralBadgeYear_AllWhite-1-281x300.png">&nbsp; &nbsp;<img src="https://www.greatplacetowork.com/images/profiles/7049203/companyBadge.png?20240207">&nbsp; &nbsp; &nbsp;<img src="https://pbs.twimg.com/media/FvJDPn0aEAAwgAH?format=jpg&amp;name=small"> &nbsp; &nbsp;<img src="https://colossal.com/wp-content/uploads/time-100.png"> <img src="https://imageio.forbes.com/dam/imageserve/65e730dcd08766cc9dbcdb47/x.jpg?format=jpg&amp;height=183&amp;width=255&amp;fit=bounds">&nbsp;</div>

Scientist, Genome Engineering

About the Job

About the Company

Colossal Biosciences

Similar Jobs

Research Engineer, Biotechnology

Research Engineer, Biotechnology

Biological Assay Group Leader

Biological Assay Group Leader

Scientist III – Strain Engineer

Scientist III – Strain Engineer

Bioprocess Operator

Bioprocess Operator

Group Leader – Bioassay Development

Group Leader – Bioassay Development

Research Scientist

Research Scientist

Scientist - Downstream Process Chemistry

Scientist - Downstream Process Chemistry

Scientist, Computational Biology

Scientist, Computational Biology

Research Associate II

Research Associate II

Scientist II

Scientist II